The question is often asked, “Where is Syria in prophecy?” How significant was the surprise bombing by Israel of a secret nuclear development site in Syria in 2011? When will the Isaiah 17 prophecy of the utter destruction of Damascus, their capital, be fulfilled? Syria’s capital, Damascus, is considered the oldest continually-inhabited city on Earth, but Isaiah predicted its sudden destruction in the distant future.
Psalm 83 also predicts a war between Israel and her neighbors that will have the support of Assyria (Including modern Syria), but this war is different from the even-greater future war of Gog and Magog (Russia with Iran and other major Islamic countries). One would expect that war to include Syria, but it is not mentioned, perhaps because it will have already been eliminated by then.
One possible scenario that would include all these factors would be an escalation of the current tensions between Israel and the Palestinians so that a regional war erupts. Russia and Iran would not be involved directly because the time is not yet right for the War of Gog and Magog, but Syria might take the lead in the regional war against Israel. If Israel were to suffer an attack from Syria by a weapon of mass destruction, they could respond with overwhelming force to utterly destroy Damascus.
Such a victory for Israel could produce the temporary peace that will exist a little later according to Ezekiel chapters 38 and 39, when the War of Gog and Magog will begin.